CYTOCHROME P-450 AND DRUG INTERACTIONS

Drugs that Induce or Inhibit Various Cytochrome P-450 Systems


 

Cytochrome P-450 1A2
INDUCERS INHIBITORS
Broccoli
Brussel Sprouts
Char-Broiled Meats
Insulin
Modafinil
Nafcillin
Nicotine
Omeprazole
Phenobarbital
Primidone
Rifampin
Tobacco
Amiodarone
Anastrozole
Cimetidine
Ciprofloxacin
Diltiazem
Enoxacin
Erythromycin
Flouroquinolones
Fluvoxamine
Grapefruite (juice)
Mexiletine
Norfloxacin
Ritonavir
Tacrine
Ticlopidine
 

Cytochrome P-450 2A6
INDUCERS INHIBITORS
  Ritonavir
 

Cytochrome P-450 2B6
INDUCERS INHIBITORS
Phenobarbital
Phenytoin
Primidone
Rifampin
Orphenadrine
Thiotepa
Ticlopidine
 

Cytochrome P-450 2C8
INDUCERS INHIBITORS
Phenobarbital
Primidone
Anastrozole
Omeprazole
 

Cytochrome P-450 2C9
INDUCERS INHIBITORS
Rifampin
Secobarbital
Amiodarone
Anastrozole
Cimetidine
Diclofenac
Disulfiram
Fluconazole
Fluvoxamine
Flurbiprofen
Fluvastatin
Isoniazid
Ketoprofen
Lovastatin
Metronidazole
Paroxetine
Phenylbutazone
Ritonavir
Sertraline
Sulfinpyrazone
Sulfonamides
Sulfamethoxazole - Trimethoprim
Troglitazone
Zafirlukast
 

Cytochrome P-450 2C18
INDUCERS INHIBITORS
  Cimetidine
 

Cytochrome P-450 2C19
INDUCERS INHIBITORS
Carbamazepine
Norethindrone
Prednisone
Rifampin
Chloramphenicol
Cimetidine
Felbamate
Fluoxetine
Fluvoxamine
Indomethicin
Ketoconazole
Lansoprazole
Modafinil
Omeprazole
Paroxetine
Probenicid
Ritonavir
Ticlopidine
Tolbutamide
Topiramate
Troglitazone
 

Cytochrome P-450 2D6
INDUCERS INHIBITORS
Dexamethasone
Rifampin
 
Amiodarone
Buproprion
Celecoxib
Chlorpromazine
Chlorpheniramine
Cimetidine
Clomipramine
Cocaine
Doxorubicin
Fluoxetine
Fluphenazine
Fluvoxamine
Haloperidol
Lomustine
Metoclopramide
Methadone
Norfluoxetine
Paroxetine
Perphenazine
Propafenone
Quinidine
Ranitidine
Ritonavir
Sertindole
Sertraine
Terbinafine
Thioridazine
Venlafaxine
Vinblastine
Vinorelbine
 

Cytochrome P-450 2E1
INDUCERS INHIBITORS
Ethanol
Isoniazid
Disulfiram
Ritonavir
 

Cytochrome P-450 3A4
INDUCERS INHIBITORS
Barbiturates
Carbamazepine
Dexamethasone
Efavirenz
Glucocorticoids
Modafinil
Nevirapine
Phenobarbital
Phenylbutazone
Phenytoin
Pioglitazone
Primidone
Rifabutin
Rifampin
St. John's Wort
Sulfinpyrazone
Troglitazone
Amiodarone
Anastrozole
Chloramphenicol
Cimetidine
Ciprofloxacin
Clarithromycin
Clotrimazole
Danazol
Delavirdine
Diltiazem
Erythromycin
Fluconazole
Fluoxetine
Fluvoxamine
Grapefruit juice
Indinavir
Itraconazole
Ketoconazole
Metronidazole
Mibefradil
Miconazole
Nefazodone
Nelfinavir
Nevirapine
Norfloxacin
Norfluoxetine
Omeprazole
Paroxetine
Propoxyphene
Quinidine
Ranitidine
Ritonavir
Saquinavir
Sertindole
Troglitazone
Troleandomycin
Verapamil
Zafirlukast
Zileuton
 

Cytochrome P-450 3A5-7
INDUCERS INHIBITORS
Phenobarbital
Phenytoin
Primidone
Rifampin
Clotrimazole
Ketoconazole
Metronidazole
Miconazole
Troleandomycin

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Updated 11/23/2003