CYTOCHROME P-450 AND DRUG INTERACTIONS

Drugs that Induce or Inhibit Various Cytochrome P-450 Systems


DRUG INDUCES INHIBITS

Amiodarone   1A2
2C9
2D6
3A4
 
Amitriptyline
2D6
 
Anastrozole
1A2


2C8


2C9


3A4
 
Barbiturates 1A2

2C19

2C9

3A4
 
Broccoli 1A2  
 
Brussel Sprouts 1A2  
 
Buproprion   2D6
 
Cannabinoids
3A4
 
Carbamazepine 2C9
2C19
3A4
 
 
Celecoxib   2D6
 
Charcoal-broiled meats 1A2
 
Chloramphenicol   2C19
3A4
 
Chlorpheniramine   2D6
 
Chlorpromazine   2D6
 
Cimetidine   1A2
2C9
2C18
2C19
2D6
3A4
 
Ciprofloxacin   1A2
3A4
 
Clarithromycin   1A2
3A4
 
Clomipramine
2D6


3A4
 
Clotrimazole   3A4
3A5-7
 
Cocaine   2D6
 
Cyclosporine
3A4
 
Danazol
3A4
 
Delavirdine
3A4
 
Desipramine
2D6
 
Dexamethasone 2D6
3A4
 
 
Diclofenac
2C9
 
Diltiazem
1A2


3A4
 
Disulfram
2C9


2E1
 
Doxorubicin   2D6
 
Efavirenz 3A4  
 
Enoxacin
1A2
 
Erythromycin
1A2


3A4
 
Ethanol 2E1
 
Ethosuximide 3A4
 
Felbamate
2C19
 
Flouroquinolones   1A2
 
Fluconazole
2C19


2C9


3A4
 
Fluoxetine   2C19
2D6
3A4
 
Fluphenazine
2D6
 
Flurbiprofen
2C9
 
Fluvastatin
2C9
 
Fluvoxamine
1A2


2C19


2C9


2D6


3A4
 
Glucocorticoids 3A4  
 
Glutethimide 3A4
 
Grapefruit (juice)
1A2


3A4
 
Griseofulvin 3A4
 
Haloperidol
2D6
 
Indinavir
3A4
 
Indomethicin
2C19
 
Insulin 1A2  
 
Isoniazid 2E1 1A2
2C9
 
Itraconazole
2C9


3A4
 
Ketoconazone
1A2
2C9
2C19
3A4
3A5-7
 
Ketoprofen
2C9
 
Lansoprazole
2C19
 
Levofloxacin
1A2
 
Lomefloxacin
1A2
 
Lomustine
2D6
 
Lovastatin   2C9
 
Metoclopramide   2D6
 
Methodone   2D6
 
Metronidazole
2C9


3A4


3A5-7
 
Mexiletine
1A2
 
Mibefradil
2D6


3A4
 
Miconazole
3A4


3A5-7
 
Modafinal 1A2
3A4
2C19
 
Nafcillin 1A2  
 
Nefazodone
2D6


3A4
 
Nelfinavir
3A4
 
Nevirapine 3A4  
 
Nicotine 1A2
 
Norethindrone 2C19  
 
Norfloxacin
1A2


2D6


3A4
 
Norfluoxetine   3A4
 
Ofloxacin
1A2
 
Omeprazole 1A2 2C19


2C8


3A4
 
Orphenadrine
2B6
 
Paroxetine   1A2
2C9
2C19
2D6
3A4
 
Perphenazine
2D6
 
Phenobarbital 1A2
2B6
2C8
3A4
3A5-7
 
 
Phenylbutazone 3A4 2C9
 
Phenytoin 1A2

2B6

3A4

3A5-7
 
Prednisone 2C19  
 
Primidone 1A2

2B6

2C8

3A4

3A5-7
 
Probenicid   2C19
 
Propafenone
2D6
 
Propoxyphene
3A4
 
Quinidine
2D6


3A4
 
Ranitidine
2D6


3A4
 
Rifabutin 3A4
 
Rifampin 1A2
2B6
2C9
2C19
2D6
3A4
3A5-7
 
 
Ritonavir
1A2


2A6


2C19


2C9


2D6


2E1


3A4
 
Saquinavir
3A4
 
Secobarbital 2C9  
 
Sertindole
2D6


3A4
 
Sertraline   2C9
2C19
2D6
3A4
 
Smoking 1A2
 
St. John's Wort 3A4  
 
Sulfamethoxazole-trimethoprim
2C9
 
Sulfinpyrazone 3A4 2C9
 
Sulfonamides
2C9
 
Tacrine
1A2
 
Terbinafine   2D6
 
Thiotepa   2B6
 
Thioridazine
2D6
 
Ticlopidine   1A2
2B6
2C19
 
Tobacco 1A2  
 
Tolbutamide
2C19
 
Topiramate   2C19
 
Troglitazone 3A4 2C9
2C19
3A4
 
Troleandomycin
3A4


3A5-7
 
Venlafaxine
2D6


3A4
 
Verapamil
3A4
 
Vinblastine
2D6
 
Vinorelbine
2D6
 
Zafirlukast
2C9


3A4
 
Zaleuton
1A2
 
Zileuton
3A4
 
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Updated 11/23/2003