CYTOCHROME P-450 AND DRUG INTERACTIONS

Drugs and the Various Cytochrome P-450 Systems That Play a Role in Their Metabolism

 
Substrate Cytochrome P-450 Involved in the Drugs Metabolism
 
Acetaminophen 1A2

2E1

3A4
 
Alfentanil 3A4
 
Alprazolam 3A4
 
Amiodarone 3A4
 
Amitriptyline 1A2

2C9

2C19

2D6

3A4
 
Amlodipine 3A4
 
Amphetamine 2D6
 
Anastrozole 3A4
 
Astemizole 3A4
 
Atomoxetine 2D6
 
Atorvastatin 3A4
 
Bepridil 3A4
 
Bisoprolol 2D6
 
Bupropion 2B6
 
Buspirone 3A4
 
Busulfan 3A4
 
Cafergot 3A4
 
Caffeine 1A2

3A4
 
Cannabinoids 3A4
 
Carbamazepine3A4
 
Carisoprodol 2C19
 
Carvedilol 2C9

2D6
 
Celecoxib 2C9
 
Cerivastatin 3A4
 
Chlorpheniramine 2D6

3A4
 
Chlorpromazine 2D6
3A4
 
Chlorzoxazone 2E1
 
Cimetidine3A4
 
Cisapride3A4
 
Citalopram 2C19
 
Clarithromycin 3A4
 
Clindamycin 3A4
 
Clomipramine 1A2

2C19

2D6

3A4
 
Clonazepam 3A4
 
Clozapine 1A2

2D6
 
Cocaine 3A4
 
Codeine 2D6

3A4
 
Cortisol 3A4

3A5-7
 
Cyclobenzaprine 1A2

2D6

3A4
 
Cyclophosphamide 2B6

2C19

3A4
 
Cyclosporine3A4
 
Dapsone2C9

3A4
 
Delavirdine3A4
 
Delaviridine2D6
 
Desipramine1A2

2D6
 
Dexamethasone3A4
 
Dexfenfluramine2D6
 
Dextromethorphan2D6

3A4
 
Diazepam1A2

2C19

2C8

3A4
 
Diclofenac2C8

2C9
 
Diltiazem3A4
 
Disopyramide 3A4
 
Divalproex sodium 2C19
 
Docetaxel 3A4
 
Dolasetron 2D6

3A4
 
Donepezil 2D6

3A4
 
Doxorubicin 3A4
 
Dronabinol 2C9
 
Efavirenz 2B6
 
Enalapril 3A4
 
Encainide 2D6
 
Enflurane 2E1
 
Ergot Alkaloids 3A4
 
Erythromycin 3A4
 
Estrogens, oral 3A4
 
Ethanol 2E1
 
Ethinyl estradiol 1A2

3A4

3A5-7
 
Ethosuximide 3A4
 
Etoposide 3A4
 
Felodipine 3A4
 
Fenfluramine 2D6
 
Fentanyl 3A4
 
Fexofenadine 3A4
 
Finasteride 3A4
 
Flecainide 2D6
 
Fluconazole 3A4
 
Fluoxetine 2C9

2D6
 
Fluphenazine 2D6
 
Flutamide 3A4
 
Fluvoxamine 1A2

2C9

2D6
 
Gleevac 3A4
 
Glimepiride 2C9
 
Glipizide 2C9
 
Glyburide 3A4

2C9
 
Granisetron 3A4
 
Haloperidol 1A2

2D6

3A4
 
Halothane 2E1
 
Hexobarbital 2C19

2C9
 
Hydrocodone 2D6

3A4
 
Hydrocortisone 2D6

3A4
 
Ibuprofen 2C9
 
Ifosfamide 2B6

3A4
 
Imipramine 1A2

2C19

2C9

2D6

3A4
 
Indinavir 2D6

3A4
 
Indomethacin 2C9

2C19
 
Irbesartan 2C9
 
Irinotecan 3A4
 
Isoflurane 2E1
 
Isoniazid 2E1
 
Isotretinoin (retinoids) 1A2

2C8

3A4
 
Isradipine 3A4
 
Itraconazole 3A4
 
Ketoconazole 3A4
 
Labetalol 2D6
 
Lansoprazole 2C19

3A4
 
Lidocaine 2D6

3A4
 
Loratadine 2D6
 
Loratadine 3A4
 
Losartan 2C9

3A4
 
Lovastatin 3A4

3A5-7
 
Maprotiline 2D6
 
Maxiletine 1A2

2D6
 
Mefenamic acid 2C9
 
Meloxicam 2C9
 
Meperidine 2D6
 
Mephenytoin 2C19
 
Mephobarbital 2C8

2C19
 
Methadone 1A2

2B6

2D6

3A4
 
Methamphetamine 2D6
 
Metoclopramide 2D6
 
Metoprolol 2D6
 
Mexiletine 2D6
 
Mibefradil 3A4
 
Miconazole 3A4
 
Midazolam 3A4
 
Mirtazapine 1A2

2C9

2D6

3A4
 
Morphine 2D6
 
Naproxen 1A2

2C9

2C18
 
Nateglinide 2C9

3A4
 
Navelbine 3A4
 
Nefazodone 3A4
 
Nelfinavir 3A4
 
Nevirapine 2C19

3A4
 
Nicardipine 3A4
 
Nicotine 2A6
 
Nifedipine 3A4

3A5-7
 
Nilutamide 2C19
 
Nimodipine 3A4
 
Nisoldpine 3A4
 
Nitrendipine 3A4
 
Nortriptyline 1A2

2D6
 
Olanzapine 1A2
 
Omeprazole 2C18

2C19

2C8
 
Ondansetron 1A2

2D6

2E1

3A4
 
Oral contraceptives 3A4
 
Oxycodone 2D6
 
Paclitaxel 2C8

3A4
 
Pantoprazole 2C19
 
Paroxetine 2D6
 
Perphenazine 2D6
 
Phenacetin 1A2

2D6
 
Phenformin 2D6
 
Phenol 2E1
 
Phenytoin 2C19

2C9
 
Pimozide 3A4
 
Piroxicam 2C18

2C9
 
Pravastatin 3A4
 
Prednisone 3A4
 
Primidone 2C19
 
Progesterone 2C19

3A4
 
Proguanil 2C18

2C19
 
Propafenone 1A2

2D6

3A4
 
Propranolol 1A2

2C18

2C19

2D6
 
Quinidine 3A4

3A5-7
 
Quinine 3A4
 
R-Warfarin 1A2

1A2

3A4
 
Rapamycin 3A4
 
Retinoic acid 2C18

2C8
 
Rifabutin 3A4
 
Rifampin 3A4
 
Riluzole 1A2
 
Risperidone 2D6
 
Ritonavir 1A2

2A6

2C19

2C9

2D6

2E1

3A4
 
Ropivacaine 1A2

2D6
 
Rosiglitazone 2C9
 
Salmeterol 3A4
 
Saquinavir 3A4
 
Selegiline 2D6
 
Sertindole 2D6
 
Sertraline 2D6

3A4
 
Sevoflurane 2E1
 
Sildenafil 2C9

3A4
 
Sirolimus 3A4
 
Simvastatin 3A4
 
Sufentanil 3A4
 
Sulfamethoxazole 2C9
 
Tacrine 1A2
 
Tacrolimus 3A4
 
Tamoxifen 1A2

2A6

2B6

2C9

2D6

2E1

3A4
 
Taxol 3A4
 
Temazepam 3A4
 
Teniposide 2C19

3A4
 
Terfenadine 3A4

3A5-7
 
Testosterone 3A4

3A5-7
 
Theophylline 1A2

2E1

3A4
 
Thioridazine 2D6
 
Tiagabine 3A4
 
Timolol 2D6
 
Tolbutamide 2C8

2C9
 
Torsemide 2C9
 
Tramadol 2D6
 
Trazodone 2D6

3A4
 
Tretinoin 3A4
 
Triazolam 3A4

3A5-7
 
Troleandomycin 3A4
 
Tropisetron 2D6
 
Valproic acid 2C19
 
Venlafaxine 2D6
 
Verapamil 1A2

3A4
 
Vinblastine 3A4

3A5-7
 
Vinca alkaloids 3A4
 
Vincristine 3A4

3A5-7
 
Warfarin 1A2

2C9

2C18

2C19
 
Yohimbine 2D6
 
Zafirlukast 2C9
 
Zaleplon 3A4
 
Zileuton 1A2

2C9

3A4
 
Zolmitriptan 1A2
 

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Updated 11/23/2003